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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CHEK2
All Species:
5.45
Human Site:
T89
Identified Species:
8.57
UniProt:
O96017
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O96017
NP_001005735.1
543
60915
T89
D
Q
E
P
E
E
P
T
P
A
P
W
A
R
L
Chimpanzee
Pan troglodytes
XP_001172779
543
60866
T89
D
Q
E
P
E
E
P
T
P
A
P
W
A
R
L
Rhesus Macaque
Macaca mulatta
XP_001102484
543
60923
A89
D
Q
E
P
E
E
P
A
P
A
P
W
A
R
L
Dog
Lupus familis
XP_543464
544
61233
V90
D
Q
E
P
E
E
P
V
P
A
P
W
A
R
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z265
546
61070
W97
E
E
P
G
P
A
P
W
A
R
L
W
A
L
Q
Rat
Rattus norvegicus
NP_446129
545
60912
W96
E
E
P
G
P
T
P
W
A
R
L
W
A
L
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508699
537
60493
Y91
L
E
C
V
L
D
D
Y
W
F
G
R
D
K
S
Chicken
Gallus gallus
NP_001073576
522
58779
W91
D
C
V
N
D
E
Y
W
F
G
R
D
K
S
C
Frog
Xenopus laevis
NP_001082016
517
58243
R89
H
E
E
Y
V
F
G
R
D
K
K
C
D
Y
T
Zebra Danio
Brachydanio rerio
Q501V0
422
47914
V16
L
P
E
P
P
G
D
V
Q
L
D
L
V
K
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O61267
476
54243
A71
L
N
N
D
E
F
T
A
G
R
G
E
A
N
D
Honey Bee
Apis mellifera
XP_624334
480
54300
K74
C
I
T
N
N
E
L
K
P
K
W
L
S
V
M
Nematode Worm
Caenorhab. elegans
Q9U1Y5
476
53320
G71
D
H
F
V
C
G
R
G
S
D
D
A
P
T
N
Sea Urchin
Strong. purpuratus
XP_794585
480
52849
F74
L
Y
P
V
G
K
C
F
S
S
I
D
F
L
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P39009
513
58614
D88
H
L
L
Q
M
D
V
D
N
F
Q
R
N
L
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99
89.3
N.A.
83.1
83.4
N.A.
74.4
67.5
59.6
28.1
N.A.
34
37.2
30.2
43.2
Protein Similarity:
100
99.8
99
93
N.A.
89.7
89.9
N.A.
82.1
77.9
73.1
41.9
N.A.
51.5
54.5
49.5
58.3
P-Site Identity:
100
100
93.3
93.3
N.A.
20
20
N.A.
0
13.3
6.6
13.3
N.A.
13.3
13.3
6.6
0
P-Site Similarity:
100
100
93.3
93.3
N.A.
33.3
33.3
N.A.
20
20
13.3
20
N.A.
13.3
26.6
6.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
28.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
47.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
7
0
14
14
27
0
7
47
0
0
% A
% Cys:
7
7
7
0
7
0
7
0
0
0
0
7
0
0
7
% C
% Asp:
40
0
0
7
7
14
14
7
7
7
14
14
14
0
14
% D
% Glu:
14
27
40
0
34
40
0
0
0
0
0
7
0
0
0
% E
% Phe:
0
0
7
0
0
14
0
7
7
14
0
0
7
0
0
% F
% Gly:
0
0
0
14
7
14
7
7
7
7
14
0
0
0
0
% G
% His:
14
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
7
0
0
0
0
0
0
0
0
7
0
0
0
7
% I
% Lys:
0
0
0
0
0
7
0
7
0
14
7
0
7
14
7
% K
% Leu:
27
7
7
0
7
0
7
0
0
7
14
14
0
27
27
% L
% Met:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
7
% M
% Asn:
0
7
7
14
7
0
0
0
7
0
0
0
7
7
7
% N
% Pro:
0
7
20
34
20
0
40
0
34
0
27
0
7
0
0
% P
% Gln:
0
27
0
7
0
0
0
0
7
0
7
0
0
0
14
% Q
% Arg:
0
0
0
0
0
0
7
7
0
20
7
14
0
27
0
% R
% Ser:
0
0
0
0
0
0
0
0
14
7
0
0
7
7
7
% S
% Thr:
0
0
7
0
0
7
7
14
0
0
0
0
0
7
7
% T
% Val:
0
0
7
20
7
0
7
14
0
0
0
0
7
7
0
% V
% Trp:
0
0
0
0
0
0
0
20
7
0
7
40
0
0
0
% W
% Tyr:
0
7
0
7
0
0
7
7
0
0
0
0
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _